Hi dtech,
you have some options:
1. Instead of using a full frame Camera, which is known for low depth of field, use a crop camera with more depth of field, a MFT-camera with even more depth of field or a good point and shot camera with again more depth of field.
2. You can use your tilted photos and mask out unsharp parts. It can be done automatically or semi automatically. (search the forum, there was a discussion about this last year).
3. Perhaps you can even stack your tilted photos (but I have never heard someone is doing this).
Is depth of field an issue for anyone else out there?
Yes, for everyone who is shooting makro photos for photogrammetry!
I then tested Helicon Focus and Remote which is a fabulous solution if you are shooting objects for just photography but for photogrammetry I couldn't imagine the headache of stacking every angle. 100 images would become 500 then back to 100.
Is anyone doing this?
Yes, I have read of someone. Indeed a lot of work, needs some automation.
Karsten