Hello Twister,
The following code should work for the chunk referenced in Local Coordinates:
import PhotoScan
side_length = 5.0 #set value here
chunk = PhotoScan.app.document.chunk
T = chunk.transform.matrix
chunk.region.center = T.inv().mulp(PhotoScan.Vector([0, 0, 0]))
chunk.region.size = PhotoScan.Vector([side_length, side_length, side_length]) / chunk.transform.matrix.scale()
chunk.region.rot = T.rotation().t()
print("script finished.")