Hi Alexey, thanks for responding.
Yes, I am using the same resolution. I Build the DEM from the mesh using the default resolution (0.00135878 m)
Then I build the orthomosaic, click the Metres... button and enter in the same resolution (0.00135878 m)
The created DEM and Orthomosaic both have same resolution (1.36 mm/pix) and the pixel sizes are exactly the same.
I checked for the shift by zooming all the way in and visually checking for difference on screen, double clicking the mosaic and then double clicking the DEM. Thats where I see the shift, less than a pixel.