Best for single CPU, some i7 4xxx or 5xxx series, best possible freq price/performance vise. Mobo that have 8 memory slots for further expanding to 64 ( 128 GB), can start with 32 GB ram, and good GPU, best if some NVIDIA, even if they are a bit slower as AMD but the drivers are much better. say card with 3-6 GB VRAM - GTX780. 780Ti is pricey and without too much speedup.