OK, I discovered the problem.
THe thing is, I'm not sitting in front of my PC which runs PS. Instead I use the remote desktop service of Windows. As it turns out, when using this, windows deactivates one of the two GPU (for which reason so ever).
I just checked some stuff directly at the PC with the two GPU and suddendly both were available, also in PS.
So, instead of using the windows internal remote desktop functionality, I'll use the Teamviewer Software, which does not cause any problems, as it should be.
Well, Alexey, maybe you should make a note of this behavior, in case it turns on again.
Cheers