I agree about the attractiveness of this feature in Pix4D, though the editing of the seamlines is a nightmare to get used to. I played around with it for an hour or so.
On the other hand, if you use it intensively on a model and say have a lot of buildings in it, you'd get a picture where every building raises into another direction. Not what I'd call a useful orthophoto.
What I'd consider much more desirable is finding a method that applies a clean texture to vertical objects, like walls. I am not an expert in it but I am surprised that there is no tool which can use existing vertical textures (like through the use of very wide angle photo lenses and intensive overlapping) and put it onto the mesh without those terrible and extreme distortions.